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Plumbagin, a naturally occurring naphthoquinone derived from various plants, has garnered significant attention in the field of dermatological research due to its multifaceted biological properties, including anti-inflammatory, antioxidant, and anticancer effects. In recent years, the modulation of melanogenesis, the process by which melanin is produced in the skin, has become a focal point of interest, particularly concerning its implications for skin pigmentation and potential therapeutic interventions for conditions such as hyperpigmentation and melanoma. Melanogenesis is largely regulated by several key factors, among which ¥á-melanocyte-stimulating hormone (¥á-MSH) plays a pivotal role. ¥á-MSH is a peptide hormone that binds to the melanocortin 1 receptor (MC1R) on melanocytes, stimulating the production of melanin through the upregulation of various melanogenic enzymes, with tyrosinase being the most critical. Tyrosinase catalyzes the key initial step in melanin synth¡¦(»ý·«)
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