1. ÇÕ¼ºµÇ´Â ´Ü¹éÁúÀÇ ¼ÒÆ÷ü·ÎÀÇ À̵¿
- ribosome¿¡¼ ÇÕ¼ºµÇ´Â polypeptide´Â ÇÕ¼ºÃʱ⿡ °ð ¼ÒÆ÷ü³»ºÎ·Î »ðÀԵǾî ÇÕ¼ºÀÌ ÁøÇà.
- ¼¼Æ÷Áú¿¡ Á¸ÀçÇÏ´Â ½ÅÈ£ÀÎÁöÀÔÀÚsignal-recognition particle (SRP: protein-RNA complex)°¡ ÇÕ¼ºµÇ´Â ´Ü¹éÁúÀÇ ½ÅÈ£¼¿°ú ribosome¿¡ °áÇÕ (´Ü¹éÁúÇÕ¼º °³½Ãº¹ÇÕü¿Í ÇÑ µ¢¾î¸®¸¦ ÀÌ·ë)ÇÑ ÈÄ, ¼ÒÆ÷ü ¸·»óÀÇ ½ÅÈ£ÀÎÁöÀÔÀÚ ¼ö¿ëüSRP receptor¿Í °áÇÕÇÑ´Ù.
- ¼ÒÆ÷ü ¸·¿¡ Á¸ÀçÇÏ´Â ÀüÁÂÅë·Îtranslocation channel·Î ÇÕ¼ºµÇ´Â ´Ü¹éÁúÀ» Àü´Þ, ´Ü¹éÁúÀº ¼ÒÆ÷ü³»ºÎ·Î »ðÀԵǸç ÇÕ¼ºÀÌ ÁøÇàµÈ´Ù.
* ¸· °üÅë ´Ü¹éÁúÀÇ Çü¼º mechanism
- ribosome¿¡¼ ÇÕ¼ºµÇ´Â ´Ü¹éÁúÀÇ À̵¿°³½Ã¼¿start-transfer sequence (signal sequence)À» ¼¼Æ÷±âÁú¿¡ Á¸ÀçÇÏ´Â ½ÅÈ£ÀÎÁöÀÔÀÚsignal-recognition particle (SRP)°¡ ÀνÄ
- ¼ÒÆ÷ü¸·¿¡ Á¸ÀçÇÏ´Â ½ÅÈ£ÀÎÁöÀÔÀÚ ¼ö¿ëüSRP receptor°¡ SRP¿Í °áÇÕ
- À̵¿°³½Ã¼¿À» ÀüÁÂÅë·Îtranslocation channel¿¡ Àü´Þ
- ´Ü¹éÁú ¼ÒÆ÷ü ³»ºÎ·Î À̵¿
- ´Ü¹éÁú ³»ºÎ¿¡ À§Ä¡ÇÏ´Â ¼Ò¼ö¼º À̵¿Á¾°á¼¿stop-transfer sequenceÀÌ ÀüÁÂÅë·Î¸¦ Åë°úÇÒ ¶§ ´Ü¹éÁúÀº ÀüÁÂÅë·Î¿¡¼ ¸·ÀÇ ÀÏ¹Ý ÁöÁúºÎÀ§·Î ¹ÐÃÄÁü.
- ´Ü¹éÁú¡¦(»ý·«)
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