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1) 蹂묓깭�깮由�
thick ascending limb of Henle`s loop �쓽 Na �옱�씉�닔 �옣�븷
-> volume depletion
-> aldosterone 遺꾨퉬利앷��
-> aldosteron �쓽 利앷����� NaCl怨� water�쓽 distal delivery 利앷��濡�
kaliuresis, hypokalemia
-> prostaglandin �깮�궛 珥됱쭊
-> renin, aldosterone 遺꾨퉬珥됱쭊
-> �삁以� bradykinin�쓽 利앷��
[ 2 ] clinical feature
1. �쟾�삎�쟻�씤 �뼇�긽 ; renal potasium wasting�뿉 �쓽�븳 hypokalemia
metabolic alkalosis
normal to low blood pressure
2. autosomal recessive 濡� �쑀�쟾�븳�떎. sporadic �븳 case�룄 議댁옱.
3. ���遺�遺� �떎�쓬�쓽 利앹꽭濡� �씤�빐 �냼�븘湲곗뿉 吏꾨떒�맂�떎.
polyuria, weakness �벑�쓽 hypokalemia�뿉 �뵲瑜대뒗 利앹꽭.
4. growth & mental retardation�씠 �삱 �닔�룄 �엳�떎.
5. renal boipsy �냼寃ъ긽
hyperplasia of juxtaglomelular apparatus
prominence of medullary interstitial cell
variable degree of interstitial fibrosis
[ 3 ] Diagnosis
hypokalemia, metabolic alkalosis, secondary hyper-reninemic hyperaldosteronism�쓣 �씪�쑝�궗 �닔 �엳�뒗 other condition��� �젣�쇅�릺�뼱�빞 �븳�떎.
vomitting, ���(�깮�왂)
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Bartter`s Syndrome.hwp
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