proteasome
- ÁøÇÙ»ý¹°¿¡ º¸ÆíÀûÀ¸·Î Á¸ÀçÇÏ´Â °Å´ë ÇÁ·ÎÅ×¾ÆÁ¦(protease, ´Ü¹éÁúºÐÇØÈ¿¼Ò)ÀÇ 1Á¾. 1980³â ÃÊ¿¡ ¼ÒÀÇ ³úÇϼöü¿¡¼ óÀ½ ¹ß°ßµÇ¾ú´Ù. È¿¸ð¸¦ ºñ·ÔÇÏ¿© ½Ä¹°°ú Æ÷À¯·ù¿¡ À̸£±â±îÁö °ÅÀÇ ¸ðµç ÁøÇÙ¼¼Æ÷ÀÇ ÇÙ°ú ¼¼Æ÷Áú¿¡ Á¸ÀçÇÏ°í ÀÖ´Ù. 700 kDa ÀÌ»óÀÇ °Å ´ëÇÑ ´Ü¹éÁú ºÐÇØ È¿¼Ò·Î¼, 21-32 kDa ¿¡ ÇØ´çÇÏ´Â 13-15 Á¾·ù ÀÌ»óÀÇ ¼·Î ´Ù¸¥ 30¿©°³ÀÇ ´Ü¹éÁú ´Ü·®Ã¼°¡ º¹ÀâÇÑ ±¸Á¶ÀÇ ¹è·² ¸ð¾çÀÇ º¹ÇÕü¸¦ ±¸¼ºÇÏ°í ÀÖ´Ù. ProteasomeÀº Àû¾îµµ ¼¼°¡Áö ÀÌ»óÀÇ ÆéƼµå ºÐÇØ È°¼º Áï, ¼Ò¼ö¼º ¾Æ¹Ì³ë»êÀÇ carboxyl residuce¸¦ ºÐÇØÇÏ´Â chymotrypsin-like activity, ¿°±â¼º carboxyl residuce ¸¦ ºÐÇØÇÏ´Â trypsin-like activity, ±×¸®°í »ê¼º ¾Æ¹Ì³ë»êÀÇ carboxyl residuce¸¦ ºÐÇØ ÇÏ´Â peptidylgutamyl-ÆéƼµå ºÐÇØ È°¼ºÀ» °¡Áö°í ÀÖ´Ù.
¼¼Æ÷³»¿¡´Â 20S¿Í 26S 2Á¾·ùÀÇ ÇÁ·ÎÅ׾ƼØÀÌ ÀÖ´Ù. 20SÇÁ·ÎÅ׾ƼØÀº ¥á¿Í ¥â 2Á¾·ùÀÇ ¼ºêÀ¯´ÖÀ¸·Î ÀÌ·ç¾îÁø´Ù. ¥á-¼ºêÀ¯´Öµµ ¥â-¼ºêÀ¯´Öµµ °¢°¢ ¼·Î »óµ¿ÀÎ 7°³ÀÇ Æú¸® ÆéƼµå°¡ µµ¿ì³Ó¸ð¾çÀ¸·Î ¹è¿ÇÑ °ÍÀÌ°í (¥á7, ¥â7), ±× À§¿¡ ±×¡¦(»ý·«)
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1. Donald voet ¿Ü 1ÀÎ, Biochemistry 2nd Edition, John Wiley & Sons-INC, 1993 2. Á¶¿Ï±Ô, ¹ß»ý»ý¹°ÇÐ, ¾ÆÄ«µ¥¹Ì ¼Àû, 1995 3. ±è âÇÑ ¿Ü 1ÀÎ, »ýÈÇÐ °è»ê¹ý, À»À¯¹®È»ç, 1986 4. Çѱ¹»ý¹°°úÇÐÇùȸ, »ý¹°ÇлçÀü, ¾ÆÄ«µ¥¹Ì¼Àû, 1998
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