1. Clomiphen citrate (clomid, serophen)
a. nature : synthetic, nonsteroidal, biologically weak long-acting estrogen agonist
b. action : competitive inhibitor of estrogen
blocking estrogen Rc at the hypothalamic & pituipaty level
- increase FSH release from pituitary by (-) feedback
c. criteria for the selection of patients for clomid
¨ç evidance of pituitary fx
¨è no evidance of primary ovarian failure
¨é normal prolactin assay
¨ê normal thyroid & adrenal fx
¨ë no other treatable cause of amenorrhea
¨ì no obvious infertility factor
d. dosage & duration
: 50-100 mg/day for 5-10 days from cycle day 3-5
(dosage¡è- FSH º¸°, duration¡è- LH º¸°)
e. monitoring
: BBT(basal body temperature, ÀϾÀÚ ¸¶ÀÚ ¿òÁ÷ÀÌÁö ¸»°í Çô ¹Ø¿¡¼ Àë)
cervical mucus(clomiphen day 12-14), E2, LH, ultrasonogram, P4,
endometrial Bx(clomiphen day 25-27)
*¡¦(»ý·«)
¨ç daily dose Áõ°¡ (FSH Áõ°¡)
¨è duration Áõ°¡ (poor estrogenic mucus -- LH Áõ°¡)
¨é administration of hCG
|