Oxidative Stress
- endogenous reactive oxygen species
; damage DNA, protein, carbohydrates, lipids --> º´À¯¹ß
e.g., hydroxyl radical, superoxide anion radical, hydrogen peroxide, 1O2, hypochlorite, nitric oxide
radical, peroxynitrite
- a major site of production for reactive oxygen species
; respiratory chain --> superoxide radical anion µîÀÌ »ý¼ºµÊ
(antimicrobial defence, inflamation, photobiological reaction µî¿¡ ÀÇÇؼµµ »ý¼ºµÊ)
- `Oxidative stress`´Â prooxidant-antioxidant balance¸¦ ±þ
; normal aerobic steady-state°¡ ±úÁö¸é¼ product¿¡ damage !
- antioxidant ¼·Ãë°¡ ºÒÃæºÐÇϸé oxidative stress »ý±æ¼öµµ ÀÖ´Ù.
- ÁÖ¿ä prooxidantÀÇ half life
hydroxyl radicals ; nanoseconds
peroxyl radicals, nitric oxide, peroxynitrite ; seconds
- oxydative stress ±Øº¹ ±âÀÛ
¨ç prevention
¨è interception ; antioxidant agent ³óµµ°¡ ³ô¾Æ¾ß ÀÛµ¿
¨é repair
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